New Discovery: Muscle strengthening Gene

Researchers have discovered a gene that stimulates muscle potency when swapped on by bodily activity, opening the potential for the evolution of therapeutic cures to imitate some of the advantages of working out.

Publicized in Cell Metabolism, the University of Melbourne-led study demonstrated how various types of workouts change the molecules in our muscles, resulting in the finding of the new C18ORF25 gene that is triggered with all types of workouts and liable for promoting muscle strength. Animals without C18ORF25 have poor workout performance and more vulnerable muscles.

 Dr. Benjamin Parker said by activating the C18ORF25 gene, the research team could see muscles become much stronger, without them becoming necessarily bigger.

“Identifying this gene may influence how we manipulate healthful aging, disorders of muscle atrophy, sports science, livestock, and meat production. This is because boosting optimal muscle function is one of the best predictors of overall health,” Dr. Parker said.

“We know exercise can prevent and treat chronic diseases including diabetes, cardiovascular disease, and many cancers. Now, we hope that by better understanding how different types of exercise elicit these health-promoting effects at the molecular level, the field can work towards making new and improved treatment options available.”

In the study, a collaboration between Dr. Parker and Professors Erik Richter and Bente Kiens of the University of Copenhagen, Denmark, the team was able to identify the molecular similarities and differences between different types of exercise in human muscle biopsies by analyzing proteins and how they change within cells.

“To identify how genes and proteins are activated during and after different exercises, we analyzed human skeletal muscle from a cross-over intervention of endurance, sprint, and resistance exercise,” Dr. Parker said.

The experimental design allowed researchers to compare signaling responses between the exercise modalities in the same individual, relative to their pre-exercise level. This meant they could monitor how an individual responded to different types of exercise directly in their muscles.

Importantly, it also allowed the study team to identify genes and proteins that consistently change across all individuals and all types of exercise, leading to the discovery of the new gene.

This work was funded by the Australian National Health and Medical Research Council project grant (APP1122376), a Diabetes Australia grant, a University of Melbourne Driving Research Momentum Grant, and an NHMRC Emerging Leader Investigator Grant (APP2009642) to Dr. Benjamin Parker.

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Materials provided by the University of Melbourne

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2 thoughts on “New Discovery: Muscle strengthening Gene

  • September 6, 2022 at 7:36 am

    Itís nearly impossible to find educated people about this subject, but you seem like you know what youíre talking about! Thanks


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